Adebayor double sinks Swansea

first_imgFor Swansea, an eighth successive league match without a win left Michael Laudrup’s men just three points above the relegation zone.The Welsh club had early chances at the Liberty Stadium, with Hugo Lloris saving Jonjo Shelvey’s long-range shot and striker Wilfried Bony hitting the crossbar when the France goalkeeper had been beaten by a powerful shot.Swansea also had appeals for a penalty rejected by referee Martin Atkinson after Ivory Coast forward Bony was pushed in the back by Spurs defender Michael Dawson inside the box.But, against the run of play, Togo international Adebayor gave Spurs a 35th minute lead when he powered in a header following an excellent first-time cross from Christian Eriksen.And the north London side made it 2-0 in the 53rd minute when Flores turned Kyle Walker’s cross into his own net with Spurs’ Nacer Chadli waiting behind him.Spurs wasted a chance to make it 3-0 when Mousa Dembele shot wide with Adebayor unmarked just yards from goal.However, Adebayor’s fury turned to joy when, moments later, Spurs again opened up the frail Swansea defence.Danny Rose did not repeat Dembele’s mistake but instead squared the ball to Adebayor who tapped from in from close range in the 71st minute.Bony pulled a goal back seven minutes later with a shot from the edge of the box but it was all too late for Swansea.“Even when they (Swansea) were having a lot of possession I thought we were the most dangerous side and it was just a matter of time before we clicked and found that final ball, and we did that many times in the second half and we could have gone on and won more comfortably,” Sherwood told Sky Sports.Turning to Adebayor, the Spurs boss added: “It’s great. It’s obviously great for the football club and great for Ade himself, who’s flying at the moment and enjoying his football.“He plays with a smile on his face and he’s finding the back of the net.”Sunday’s other top-flight match sees high-flyers Chelsea at home to Manchester United.The Blues will kick off nine points in front of faltering champions United, who will be without injured striker Wayne Rooney and Robin van Persie.Victory for Jose Mourinho’s Chelsea would see them move to within a point of league leaders Arsenal.By contrast, a United defeat at Stamford Bridge would increase the pressure on boss David Moyes, whose team are currently an unusually lowly seventh in their first season since the retirement of Alex Ferguson, Britain’s most successful manager.0Shares0000(Visited 1 times, 1 visits today) 0Shares0000LONDON, January 19 – Emmanuel Adebayor scored twice as Tottenham Hotspur moved level on points with fourth-placed Liverpool in the Premier League after a 3-1 win away to struggling Swansea on Sunday.Adebayor’s goals, separated by a Chico Flores own-goal, ensured Tottenham remained unbeaten in the league under manager Tim Sherwood, whose record now stands at five wins and a draw since the Englishman replaced sacked predecessor Andre Villas-Boas.last_img read more

Transfer report: Inter Milan preparing January bid for Liverpool star Emre Can

first_img1 Liverpool midfielder Emre Can is a target for Inter Milan and Juventus Inter Milan are preparing an offer for Liverpool midfielder Emre Can amid strong interest from Serie A rivals Juventus.The talented Germany international is out of contract in the summer and therefore allowed to negotiate with non-English clubs from January.Can is an important member of the Liverpool first team and has started ten of the club’s 15 Premier League games so far this season, scoring once.However he is still yet to agree a contract extension leading to suggestions he is ready to try his hand elsewhere.Serie A champions Juve have been heavily linked with a free transfer for the 23-year-old while Real Madrid are also monitoring the situation.But now, according to Tuttosport, a second Italian club have entered the race and are ready to make their presence felt in the New Year.Inter Milan are reportedly ready to offer him a pivotal role in their 4-3-3 formation and will be able to pay handsomely too.The San Siro club are currently top of Serie A and well on course to get back into the Champions League which could also be key to Can’s final decision.last_img read more

Woman surrenders after video shows kids directed to shoplift

first_img 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREFrumpy Middle-aged Mom: My realistic 2020 New Year’s resolutions. Some involve doughnuts.The video, taken Aug. 2 at a store called the Consignment Gallery, shows one woman, possibly the children’s mother, directing them to pocket certain items. An older woman, thought to be the grandmother, stuffs items down her shirt. BEDFORD, N.H. – A woman turned herself in to police Wednesday after a store surveillance video captured footage of two small children sneaking behind display cases to steal thousands of dollars in jewelry, apparently on instructions from their mother and grandmother. Bedford police made the video public this week and started getting tips minutes after it aired on local television. Police Chief David Bailey said the woman, whom he declined to identify, was not immediately arrested because there was no warrant. The woman said she lives in the area and has four children, one age 14 and three under 10, Bailey said. All are believed to have been involved, he said. last_img read more

These Liverpool fans were ‘gutted’ Fabinho didn’t start against Bayern Munich

first_img Top nine Premier League free transfers of the decade Liverpool fans are not happy to see Fabinho on the bench RANKED Klopp has surprisingly left Fabinho out of the starting XI Leaving Fabinho on the bench makes absolutely no sense but not much we can do about it. Really hope Klopp proves us all wrong but I’m seriously questioning his decision making now. It’s filled with biases, 3 runners will not compensate for technical quality against Bayern #LFC— Ragh (@redphoenixSD) March 13, 2019 When you realise Fabinho is not starting… #LFC pic.twitter.com/sHCM1f5mk6— Ashley (@ash_tw1) March 13, 2019 Neither side could find the net in the first leg Every time Ally McCoist lost it on air in 2019, including funny XI reactions Son ban confirmed as Tottenham fail with appeal to overturn red card Ronaldo warned Lukaku how hard scoring goals in Serie A would be before Inter move REVEALED Why in must win games does Klopp always fall back to Milner and Henderson? It’s the reason we haven’t won in last 6 away CL games. Fabinho missing out again…crazy. #assisgoing #LFC #ChampionsLeague— Gareth King (@GARETH_KING1) March 13, 2019 Klopp is starting with his tried and tested midfield 3 which last won a big game………………………..🤔🤔🤔 and no Fabinho 🙄🙄 #BAYLIV #UCL #LFC— Man Like Matt @TFBS (@Matt_TFBS) March 13, 2019 3 3 3 huge blow I hope I’m wrong but Gini Henderson and Milner playing together hasn’t worked all season, I can’t believe Fabinho isn’t playing #LFC— Jamie McLaughlin (@theliverword) March 13, 2019 REPLY An obvious team selection from Klopp. Gutted Fabinho isn’t starting, he’s been our best midfielder for months #lfc #LFCFamily— King in the North (@Rushie27) March 13, 2019center_img BEST OF Oxlade-Chamberlain suffers another setback as Klopp confirms serious injury Their wishes to see Fabinho play were granted on twelve minutes, however, as Jordan Henderson was forced off following a collision with James Rodriguez.Below you can see the best Fabinho tweets from these Liverpool fans. Fabinho should definitely be starting this game. We’ve left our best midfielder out of our biggest game of the season. I’m trying to tell myself the brexit midfield will replicate Roma at Anfield but too many performances this season would tell me otherwise. #BAYLIV #LFC— Tom W (@Valiant_Virgil) March 13, 2019 Where Ancelotti ranks with every Premier League boss for trophies won I wouldn’t say I’m surprised Milner starts, he’s a Klopp favourite in big away games. But I am definitely surprised that Fabinho misses out. #LFC #BAYLIV— Neil Jones (@neiljonesgoal) March 13, 2019 When you see Fabinho on the bench #LFC #BAYLIV #UCL pic.twitter.com/cEjm8dwfCi— Thomas M. Svendsen (@ThomasMSvendsen) March 13, 2019 LATEST FOOTBALL NEWS no dice It’s all to play for at the Allianz Arena as Liverpool take on Bayern Munich for a place in the Champions League quarter-finals – a game you can listen to live on talkSPORT now.The two teams start the game on level terms after playing out a goalless draw in the first leg of the last-16 tie at Anfield. ADVICE Fabinho not starting, what’s going off?? #LFC— Lewis (@lewislowbridge) March 13, 2019 REVEALED Berahino hits back at b******t Johnson criticism – ‘I was in a dark place at Stoke’ Bayern Munich vs Liverpool confirmed teamsKlopp said in his pre-match interview with BT Sport that Fabinho is on the bench because he has had a run of games, while the likes of Henderson and Milner, who didn’t feature against Burnley are fresher legs against a Bayern side who are expected to have lots of possession.Some Kopites are less than convinced, however and took to Twitter to voice their outrage at seeing Fabinho not make the starting line-up. The dreaded Milner-Henderson-Wijnaldum midfield again tonight. Hope Klopp finally realises that it does not work. Cannot believe Fabinho isnt starting. #LFC— Lewis Williams (@LewisLFC91) March 13, 2019 Which teams do the best on Boxing Day in the Premier League era? However, Reds boss Jurgen Klopp made a shock admission from his starting XI, as midfielder Fabinho is dropped to the bench.The Brazilian played a full 90 minutes of Liverpool’s victory over Burnley on Sunday and has been one of their best performers all season.But Klopp has elected to play Georginio Wijnaldum, Jordan Henderson and James Milner in the midfield three.last_img read more

Spurs star signs new deal, Zaha ‘devastated’, David Luiz ‘a gamble’, plus more

first_img three-way race Where every Premier League club needs to strengthen in January moving on The summer transfer window is over after what was actually a pretty decent deadline day. Here’s a round-up of all the fallout and latest news from today’s newspapers and online… Cavani ‘agrees’ to join new club and will complete free transfer next summer Manchester United backed out of a move for 33-year-old striker Mario Mandzukic due to Juventus’ reported €15m asking price and the Croatian’s wage demands. (ESPN)Real Madrid believe the door is closed on a move for French midfielder Paul Pogba this summer after United did not strengthen their midfield on deadline day. (Marca)The Bernabeu giants will now instead turn their focus to Paris Saint-Germain’s Brazil forward Neymar, 27. (Marca)David Luiz decided to swap Chelsea for Arsenal in an £8m deadline day move due to fears over his first-team role under former Blues team-mate and new manager Frank Lampard. (Evening Standard) Tony Cascarino backs Everton to sign two strikers for Carlo Ancelotti getty 3 3 Arsenal transfer news LIVE: Ndidi bid, targets named, Ozil is ‘skiving little git’ Signed, sealed, delivered 🤩✍️ @kierantierney1 x @DavidLuiz_4 ✍️#TimeForTierney 🏴󠁧󠁢󠁳󠁣󠁴󠁿 #BemvindoDavid pic.twitter.com/qyDUbUvGuT— Arsenal (@Arsenal) August 9, 2019Everton were not prepared to meet Manchester United’s asking price for 29-year-old Argentina defender Marcos Rojo. (Sky Sports)Rojo was left fuming after his proposed move to Everton fell through. (Daily Mail)Louis Saha says Man United’s decision not to sign Tottenhamdefender Toby Alderweireld is a “complete mystery”. (Manchester Evening News)United rejected the opportunity to sign Italy striker Moise Kean from Juventus, prior to the 19-year-old’s move to Everton. (90min) Former Arsenal defender Martin Keown tells talkSPORT signing David Luiz is a gamble. (FULL STORY)Trevor Sinclair tells talkSPORT that Manchester United will struggle to compete in the top six following a mixed transfer windowKieran Tierney will challenge the perceived view about a lack of talent in Scottish football, former Celtic team-mate Ryan Christie believes (FULL STORY)Wilfried Zaha was left devastated after a deadline day move to Everton did not materialize, and remains adamant that he wants to leave Crystal Palace. (Daily Telegraph)But Zaha fears his chances of a big-money move have now gone following Thursday’s deadline. (Daily Mail)Palace manager Roy Hodgson dismissed Zaha from training on Thursday because the player was “not in the right frame of mind” after handing in a transfer request on Wednesday. (Daily Mirror)Manchester United backed out of a move for 33-year-old striker Mario Mandzukic due to Juventus’ reported €15m asking price and the Croatian’s wage demands. (ESPN) Zaha is gutted his Everton move fell through over Crystal Palace’s £80m price tag, as Everton signed Arsenal’s Alex Iwobi instead for half getty target center_img Chelsea confident of beating Man United and Liverpool to Sancho signing Dybala’s surprise move from Juventus to Tottenham was scuppered on deadline day TOP WORK targets Liverpool’s signings under Michael Edwards – will Minamino be the next big hit? Kevin De Bruyne ‘loves Man City and wants to keep winning’, reveals father Lucas Moura has signed a new five-year contract at Tottenham (FULL STORY)Marco Silva has spoken about missing out on Wilfried Zaha as well as revealing his delight at signing Alex Iwobi (FULL STORY)Tottenham’s deadline day move for Juventus forward Paulo Dybala fell through due to complications surrounding an image rights issue. (ESPN)Spurs requested help from Juventus to pay Dybala’s image rights – support the Italian champions were not prepared to offer. (90min)Tottenham believed that they had a £64m deal in place for the 25-year-old Argentine, but Juventus became less keen on a deal following target Romelu Lukaku’s decision to join Inter Milan from Manchester United. (Daily Telegraph) LIVING THE DREAM 3 LATEST targets 👍 | THUMBS UP!Not a bad Thursday, right #InterFans? 😉⚫️🔵#WelcomeRomelu #NotForEveryone #FCIM pic.twitter.com/EmQXVsNs1F— Inter (@Inter_en) August 8, 2019Tottenham were left frustrated by Sporting Lisbon’s refusal to lower their asking price for 24-year-old Portugal midfielder Bruno Fernandes. (Daily Mirror)Meanwhile, Watford had a late bid rejected by Tottenham for England defender Danny Rose, 29. (Sky Sports)Burundi striker Saido Berahino – who was absolutely destroyed by Glen Johnson on talkSPORT on Thursday – will sign for Belgian club Zulte Waregem following his release by Championship side Stoke City. (Daily Mail) LATEST TRANSFER NEWS AND RUMOURS Tottenham line up bid for West Ham star who was labelled a ‘monster’ by Mourinholast_img read more

September 2018 User Experience and Web Professional Events

first_imgWhether you’re a user experience or web professional, you know it can be a challenge to keep your skills up-to-date, learn about new methods, and network with fellow web workers.And it takes time to find interesting local events.That’s why I publish a monthly calendar of user experience and web professionals events for southeast Michigan and northwest Ohio. The Detroit Month of Design, two accessibility meetups, and sharing your favorite productivity tools and tips are a few of the events you’ll discover in my September 2018 calendar.While I don’t attend every event on the calendar, I usually make it to one or two events each week. I’d love to meet you.When you see me, stop by and say hi!Detroit Month of DesignDate: Various events, workshops, discussions throughout September 2018Location: Throughout the city of DetroitCost: Free and paid events. Check the Detroit Month of Design schedule. Celebrating Detroit’s designation as a UNESCO City of Design, the Detroit Month of Design returns this month with partner organizations across Detroit sharing their ideas and works. I think there’s an event every day! And there’s something for everyone from panel discussions, workshops, installations, architectural walking tours, design crawls, and more. Let’s Talk About AccessibilityDate: September 5, 2018 at 6:30pmLocation: Traffic Jam in midtown Detroit, Michigan (map and directions to Traffic Jam)Cost: Free, pre-registration is requiredYou’re invited to join our Refresh Detroit group for a casual meetup to discuss web accessibility and inclusive design. No planned presentation, just a discussion of web accessibility, what you’re interested in, and where you are in your journey in learning more.Accessible JavaScript: A Practical Guide with Colin FultonDate: September 10, 2018 at 6:00pmLocation: Pillar in Ann Arbor, Michigan (map and directions to Pillar)Cost: Free, pre-registration requiredFor their September meetup, the Southeast Michigan JavaScript group hosts Colin Fulton, who will present a hands-on guide about JavaScript and website accessibility. Learn how to test JavaScript components, discover what APIs and tools are available. Lightning Talks: Automation in TechDate: September 11, 2018, at 6:30pmLocation: Bamboo Detroit in Detroit, Michigan (map to Bamboo Detroit)Cost: Free, pre-registration requiredJoin Integral Detroit for a series of lightning talks on automation and its role in current and future technology spaces. Several speakers will discuss automation from the perspective of ethics to productivity. Share Your Favorite Productivity Tool or TipDate: September 18, 2018, from 6:30pm to 8:00pmLocation: Grand Traverse Pie Company in Plymouth, Michigan (map and directions to Grand Traverse Pie Company)Cost: free, pre-registration requiredWhether you’re a designer, writer, business owner, developer, project manager, or digital marketer, you can always use productivity tips to keep your work and life running smoothly.For our September meetup, our West Metro Detroit WordPress members will share some of their favorite productivity tools/tips that make their work easier. I’ll be giving a quick intro to using Canva, the online graphic editor. Join us! Live-Blogging, Static Site Generation and You!Date: September 19, 2018, from 6:00pm to 8:00pmLocation: WeWork Campus Martius in Detroit, Michigan (map and directions to WeWork Campus Martius)Cost: $5.00, pre-registration requiredAt the Laracon conference in July 2018, Chris Forrence decided to live-blog the conference. But he didn’t want to use Google Docs. At our second Refresh Detroit event for the month, you’ll find out how Forrence leveraged Netlify, Jigsaw, GitLab, and Sublime Text to publish the live blog. My WordPress JourneyDate: September 24, 2018, from 6:30pm to 8:00pmLocation: Grand Circus in Detroit, Michigan (map and directions to Grand Circus)Cost: $5.00, pre-registration requiredFor our September meetup, three Metro Detroit WordPress meetup members will share their WordPress journey. They’ll talk about how they first discovered WordPress, what they thought of it, and what they used before WordPress to create websites. It’s always fascinating to hear the backstories and aha! moments with WordPress.Share EventsIt’s impossible to include every event happening in our area. If you know of any southeast Michigan or northwest Detroit events not on the list, share them in the comments.I ask that you only share events that have already posted their event info with date and time, thanks!Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Click to print (Opens in new window)Like this:Like Loading…RelatedSeptember 2019 User Experience and Web Professional EventsWhat user experience (UX) and web professional events are happening this month in southeast Michigan? Find out in my monthly events calendar! If you work on the web, you know it’s a challenge to keep your skills up-to-date, learn about new methods, and network with fellow web workers. And it…In “Calendar”September 2017 User Experience and Web Professionals EventsA five-day design festival, WordPress child themes presentation, and an evening of lightning talks are a few of the events you’ll discover in the September 2017 events calendar. Each month I compile a calendar of user experience and web professionals events in southeast Michigan and northwest Ohio where you’ll find…In “Calendar”September 2015 User Experience and Web Professionals EventsAn accessibility summit conference, North America’s annual festival of independent design, and an evening of user experience lightning talks are a few of the events you’ll discover in the September 2015 events calendar. Each month I compile a calendar of user experience and web professionals events in southeastern Michigan where…In “Calendar”last_img read more

Weekly Report from Washington, D.C.

first_imgDuring the week of April 23, lawmakers continued to discuss tax law changes under the Tax Cuts and Jobs Act, as well as the possibility of a second tax bill this year. The IRS is currently reviewing a series of questions from bipartisan House lawmakers on the IRS’s Tax Day systems glitch.CongressThe Joint Committee on Taxation (JCT) issued reports on federal tax baseline projections and macroeconomic modeling. Also, the JCT issued a report on solvency of multiemployer pension plans.House. A bipartisan group of House Ways and Means Committee tax writers sent Acting IRS Commissioner David Kautter a letter expressing certain concerns.Senate. The Senate Finance Committee (SFC) held an April 24 hearing to examine early impressions of the new tax law.TreasuryProactive processes to identify and mitigate potential misuse of electronic payments systems are needed, according to a report by the Treasury Inspector General for Tax Administration (TIGTA Ref. No. 2018-40-031)In addition, the Treasury has outlined its progress in enforcing President Trump’s regulatory reform, undertaken primarily to alleviate unnecessary regulatory burdens, (TDNR SM-0366)IRSMeanwhile, the IRShas updated FAQs on ACA coverage, medical expense deductions and more.Delegated authority on matters related to agent for consolidated group.will provide guidance on the new information reporting obligations for certain life insurance contract transactions under Code Sec. 6050Y. The IRS has delayed reporting requirements under Code Sec. 6050Y until the final regulations are issued, (IR-2018-104; Notice 2018-41).will host webcasts for National Small Business Week, April 29 to May 5, (IR-2018-105).extended temporary relief provided for Wisconsin energy emergencies (Notice 2018-39).will spotlight cybersecurity awareness through Nationwide Tax Forums during 2018 given the recent tax law modifications and the prevailing cybersecurity threat, (IR-2018-106).modified the annual limit on 2018 HSA contribution deductions for individuals with family coverage under a high deductible health plan (HDHP) (IR-2018-107; Rev. Proc. 2018-27).provided the  general rules and specifications for reproducing paper and computer-generated substitute for certain forms, (Rev. Proc. 2018-24).warned taxpayers of a new twist on an old phone scam as criminals use telephone numbers that mimic IRS Taxpayer Assistance Centers (TACs) to lure them into paying nonexistent tax bills, (IR-2018-103).clarified the difference between initial contacts and contacts for investigative collection.issued tips on income received as tips, what to do after tax-filing deadline and amending tax returns.spotlighted Taxpayer Bill of Rights: Right to a Fair and Just Tax System.released a Fact Sheet regarding depreciation deductions that were changed by the Tax Cuts and Jobs Act (P.L. 115-97), (FS-2018-9).RatesIn addition, the IRS provided the:applicable federal rates for May 2018 (Rev. Rul. 2018-12);nationwide average purchase price of residences in the United States to issuers of qualified mortgage bonds and mortgage credit certificates (Rev. Proc. 2018-28);nonconventional source fuel reference price for calendar year 2017, (Notice 2018-32); andforeign housing expense exclusion/deduction amounts for tax year 2018, (Notice 2018-33).Finally, the Advisory Committee on Tax Exempt and Government Entities (ACT) will hold a public meeting on Thursday, June 7, 2018.An energy company could not include hedging gains and losses in its income because the law specifically limits the definition of income to income from oil and gas property.Login to read more tax news on CCH® AnswerConnect or CCH® Intelliconnect®.Not a subscriber? Sign up for a free trial or contact us for a representative.last_img read more

Hacking People is the Easiest Way to Undermine Security

first_imgIn cybersecurity, hacking people is much easier than overcoming advanced technical defenses.  Attackers are refining their social engineering techniques, the practice of exploiting people to compromise a system, to deploy their malicious capabilities and do harm.  Social engineering continues to be a significant security problem for the industry, even in the face of improving security technologies.As Sun Tsu stated over two thousand years ago, “It is best to win without fighting”.  Why effort overcoming all the technical barriers, when people are the easiest avenue to success?  Attackers are smart.  They tend to follow the path of least resistance in pursuit of their goals.  With ~80% of workers unable to detect the most common and frequently used phishing scams, attackers are winning when they target human behaviors.Even the most serious investments in security technology can be undermined by poor human behaviors.  Making the castle walls tall and thick will be meaningless if the guards at the gate let everyone in.  This is exactly why attackers have historically maneuvered to manipulate victims into making bad decisions.  In the digital world, it can be as simple as luring an unsuspecting target to click on a malicious link in an email or visit an infected website, which initiates a chain of events to undermine the security and unravel an entire network.  It is that easy.Raj Samani, Intel Security EMEA CTO and Charles McFarland have released a report Hacking the Human Operating System which outlines the challenges to the cybersecurity community.  They describe the hunting and farming techniques, discuss the social engineering attack lifecycle, and provide a number of defenses against these types of attacks.Social engineering attacks are not going away anytime soon.  They are evolving to become more effective and represent a significant risk to the security of every person and organization connected to the Internet.  Security fundamentals include a combination of both technical and behavioral controls.  People are part of the battlefield and can be the greatest weakness or asset.  We all must make hacking humans a more difficult proposition for cyber attackers.Twitter: @Matt_RosenquistOpens in a new windowIT Peer Network: My Previous PostsLinkedIn: http://linkedin.com/in/matthewrosenquistOpens in a new windowlast_img read more

Updated: Companies settle gene technology patent fight that was shrouded in mystery

first_img*Update, 22 August, 2:45 p.m.: Illumina Inc. and Oxford Nanopore Technologies have reached a settlement in this legal battle, according to a U.S. International Trade Commission document released last week. Oxford has agreed not to import or sell any product containing a pore with an amino acid sequence at least 68% similar to Mycobacterium smegmatis porin (Msp)—the protein at the heart of Illumina’s infringement claim—and to destroy any inventory of such products.  The document explicitly states that the restriction doesn’t affect Oxford’s ability to use CsgG, a different pore that the company unveiled shortly after the suit was filed, and which underlies its newest line of sequencers. Whether Oxford ever did rely on Msp is still a mystery.Here is our original story from 2 March: The inexpensive and portable approach to DNA analysis known as nanopore sequencing has just begun to take off, but it has already sparked a legal battle between an industry giant and a high-profile upstart. Last week, Illumina, Inc.—which dominates the genetic sequencing industry—sued Oxford Nanopore Technologies, the first company to market a commercial nanopore platform. Illumina claims that Oxford’s two flagship devices infringe on patents that Illumina controls.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)The battle, closely watched by researchers who already rely on Oxford’s products, hinges on the details of a technology that are still secret, and could lead the two firms into a murky corner of patent law. Illumina leads the sequencing market, selling refrigerator-sized devices that read DNA by building and piecing together short complementary strands that bear chemical tags. In contrast, nanopore sequencing—which has been hailed as a game-changing approach to DNA analysis because of its simplicity and portability—reads long strands of DNA in a single pass, by measuring changes in electrical current as each nucleotide passes through a microscopic pore. Since 2014, Oxford has made its handheld MinION nanopore device available to researchers through an early access program, and is preparing to debut a larger and more powerful model called PromethION.Illumina, meanwhile, has yet to release a nanopore platform, but it has licensed two key patents from the University of Washington, Seattle, and the University of Alabama, Birmingham. Those patents describe a system using bacteria-derived pores known as Msp. In the new lawsuits, filed 23 February with the U.S. International Trade Commission and in a Southern California federal district court, Illumina contends that this Msp pore also underlies Oxford’s products.But the exact contents of Oxford’s machines are still a mystery, even to the researchers who have been using them. “No one I know has any specific idea about what the pore is,” says Winston Timp, a biomedical engineer at Johns Hopkins University in Baltimore, Maryland.  It’s clear that Oxford has worked with Msp pores and made them available to researchers: Among the evidence Illumina provides in the lawsuit is Oxford’s patent on a mutated form of Msp; it claims the pore makes it easier to identify the nucleotides passing through. There’s also a recent paper, which acknowledges Oxford for providing Msp pores to Harvard University researchers.  But Timp notes that the company also holds patents on other types of nanopores, including some synthetic pores developed in his lab that aren’t derived from bacteria. And the illustrations in the company’s promotional materials, he notes, look more like the α-hemolysin, a different bacterial pore developed before Msp pores.If the Oxford devices do contain an Msp pore, does that mean the company has infringed on Illumina’s patents? Not necessarily, says Dan Burk, a law professor at the University of California, Irvine. Illumina’s chance of winning the case might come down to a “very messy” aspect of patent law called the doctrine of equivalents, he says. The doctrine holds that a party can be liable for infringement even if their product doesn’t literally match what’s described in a patent, provided their product performs the same function, in the same way, to achieve the same result as the patented invention.“It’s supposed to be a way of bringing some fairness into the system, because … it’s hard to capture exactly what you’ve invented in words sometimes,” says Arti Rai, a patent law expert at Duke University in Durham, North Carolina. If Oxford’s pore contains a different set of mutations than those in Illumina’s patents, a jury might be asked to determine whether there has still been infringement by equivalents. “It’s a very fuzzy doctrine, to put it mildly,” Rai says, and judges have recently seemed reluctant to allow the argument in court.In all likelihood, the two companies would reach a settlement before that point, she adds. But if Oxford chooses to fight, it could try to show that its technology doesn’t infringe by revealing what’s under the hood of its devices to the jury, and to Illumina’s lawyers. For Illumina’s researchers, and the scientists already making use of the sequencers, that technology could still remain a mystery.last_img read more

India’s first transgenic food crop edges toward approval

first_imgNEW DELHI—India has moved a big step closer toward embracing its first genetically modified (GM) food crop. In a safety review released yesterday, the environment ministry finds that GM mustard “does not raise any public health or safety concerns for human beings and animals.”Backers feel vindicated. “The biosafety study that has been carried out is as thorough as it can be, and now ideology should not overwhelm scientific evidence,” says Deepak Pental, a plant geneticist at the University of Delhi here who developed the GM variety. Critics are unswayed. “The conclusions are based on inadequate experimentation,” says Pushpa M. Bhargava, a plant molecular biologist and former director of the Centre for Cellular and Molecular Biology in Hyderabad, India. Bhargava acknowledged that he had not fully read the report before ScienceInsider went to press.India in 2004 introduced GM cotton, which now comprises more than 90% of all cotton cultivated in the country. But it has been leery of allowing widespread cultivation of GM food crops. In 2010, the environment ministry put on hold the commercial planting of GM brinjal, an eggplant variety, equipped with a bacterial gene that thwarts insect pests. 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India is one of the world’s biggest producers of mustard (Brassica juncea), which is cultivated for its edible leaves and oil. The GM variety is equipped with genes from a soil microbe that manipulate pollen development such that the variety produces hybrids more easily in the usually self-pollinating crop. The GM-derived hybrids produce about 25% more seeds—and thus more oil, which is pressed from the seeds—than traditional varieties now in cultivation.The 133-page safety review raises one cautionary note: It calls for more studies on whether GM mustard could harm honey bees and honey production in mustard-growing areas. And it calls for continued monitoring of insects and other organisms that live in or near mustard fields.Following a 30-day comment period, the environment ministry’s Genetic Engineering Appraisal Committee will pass judgment on whether GM mustard is safe for planting and human consumption. Bhargava, a staunch GM critic, is calling on the ministry to release the raw data underlying the review’s conclusions. If the committee is favorable to GM mustard, the environment and agriculture ministers would have final say on whether to introduce the variety into farmers’ fields.last_img read more