‘Liquid biopsy’ promises early detection for cancer

first_img A screening scorecard A new cancer blood test worked better for some types than others, and caught only 43% of stage 1 cancers. (Error bars represent 95% confidence intervals.) J. COHEN ET AL., SCIENCE 10.1126/SCIENCE.AAR3247, 2018, ADAPTED BY A. CUADRA/SCIENCE Genetic mutations drive the growth of cancer cells, and dying cells shed some of this mutated DNA into the blood. The Johns Hopkins group and others have shown that so-called liquid biopsies of blood-borne tumor DNA can reveal, for example, whether a patient’s cancer should respond to a specific drug. But detecting the scant DNA released by early stage tumors is still challenging. Companies such as the $1 billion Grail, launched in 2016 by sequencing giant Illumina, are using a big data approach, sequencing hundreds of genes in thousands of cancer patients’ blood in search of a definitive set of DNA markers.The Johns Hopkins researchers and collaborators found that gains in the detection rate tailed off when they added more genes to their test. They decided to sequence parts of just 16 genes often mutated in different types of cancer. They then added eight known protein biomarkers characteristic of specific kinds of cancer. This bumped up sensitivity and allowed the team to home in on the tissue type of the tumor. ‘Liquid biopsy’ promises early detection for cancer In blood samples from 1005 patients with eight types of tumors that had evidently not yet metastasized, the test detected between 33% and 98% of cases, depending on the tumor type (see graph, above). The sensitivity was 69% or higher for ovarian, liver, stomach, pancreatic, and esophageal cancers—all types that are difficult to detect early.The test rarely found cancer that wasn’t there. Only seven of 812, or less than 1%, of healthy controls tested positive. And the test, called CancerSEEK, narrowed the origin of the cancer to two possible sites in about 80% of patients. The team, which is applying for patents on CancerSEEK, estimates the cost at less than $500 per sample. “That’s a very attractive number,” says molecular pathologist Anirban Maitra of the MD Anderson Cancer Center in Houston, Texas, because it is in the range of other cancer screening tests such as colonoscopy.Maitra and others point to caveats, however. One is that the cancer-related proteins used by the test reflect tissue damage and can also appear in people with inflammatory diseases such as arthritis. That means the 1% false positive rate will likely be higher in less healthy populations, notes proteomics researcher Lance Liotta of George Mason University in Manassas, Virginia. What’s more, the 1005 patients already had cancer symptoms; CancerSEEK probably won’t work as well in asymptomatic patients whose smaller tumors may shed less DNA. In fact, the test picked up only 43% of very early, stage 1 cancers. “We’re still not there yet,” Bardelli says.The Johns Hopkins team thinks Cancer-SEEK is ready for testing as a screening tool. “A test does not have to be perfect to be useful,” Papadopoulos says. In collaboration with Johns Hopkins, the Geisinger Health System in Pennsylvania has already begun to use CancerSEEK on blood samples from female volunteers between ages 65 and 75 who have never had cancer. The planned $50 million, 5-year study of up to 50,000 women is being funded by a private philanthropic group, The Marcus Foundation.For those who test positive twice, the next step will be imaging to find the tumor. But that will bring up questions raised by other screening tests. Will the test pick up small tumors that would never grow large enough to cause problems yet will be treated anyway, at unnecessary cost, risk, and anxiety to the patient? Papadopoulos thinks the problem is manageable because an expert team will assess each case. “The issue is not overdiagnosis, but overtreatment,” he says.Still, others working on liquid biopsies say that it will take time to figure out whether widespread screening of healthy people with a universal blood test can reduce cancer deaths without doing harm. “If people expect to suddenly catch all cancers, they’ll be disappointed,” says cancer researcher Nitzan Rosenfeld of the University of Cambridge in the United Kingdom. “This is exciting progress,” he says. “But evaluating it in the real world will be a long process.” Anne Weston/Cancer Research UK/Visuals Unlimited, Inc. center_img By Jocelyn KaiserJan. 18, 2018 , 2:00 PM 100OvaryCases detected (%)LiverStomachPancreasEsophagusColorectumBreastLung806040200 A team of researchers has taken a major step toward one of the hottest goals in cancer research: a blood test that can detect tumors early. Their new test, which examines cancer-related DNA and proteins in the blood, yielded a positive result about 70% of the time across eight common cancer types in more than 1000 patients whose tumors had not yet spread—among the best performances yet for a universal cancer blood test. It also narrowed down the form of cancer, which previously published pan-cancer blood tests have not.The work, reported online today in Science, could one day lead to a tool for routinely screening people and catching tumors before they cause symptoms, when chances are best for a cure. Other groups, among them startups with more than $1 billion in funding, are already pursuing that prospect. The new result could put the team, led by Nickolas Papadopoulos, Bert Vogelstein, and others at Johns Hopkins University in Baltimore, Maryland, among the front-runners.”The clever part is to couple DNA with proteins,” says cancer researcher Alberto Bardelli of the University of Turin in Italy, who was not involved in the work. The researchers have already begun a large study to see whether the test can pick up tumors in seemingly cancer-free women.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*) A new blood test looks for DNA shed by tumor cells, such as these pancreatic cancer cells.last_img read more

WWE legend Rick Flair vows to ‘never drink again’ after near-death experience

first_imgMOST READ Argentine bishop appears at court hearing on abuse charges Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Still, the “Limousine Ridin’, Jet Flyin’, Kiss Stealin’, Wheelin’ Dealin’, Son of a Gun” said he remained sober while performing for his countless fans.“I never drank when I was working,” he said. “But as soon as work was over, I went right to the mill.”  Khristian Ibarrola /raSports Related Videospowered by AdSparcRead Next No more menthol cigarettes: New ban on tobacco, vape flavors View comments Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Retired professional wrestler Rick Flair, the subject of the documentary “30 for 30: Nature Boy” participates in a panel during the ESPN Television Critics Association Summer Press Tour at the Beverly Hilton on Wednesday, July 26, 2017, in Beverly Hills, California.  (Photo by Chris Pizzello/Invision/AP)Aside from his trademark “Woo!” yell, World Wrestling Entertainment (WWE) Hall of Famer Rick Flair is perhaps best known for his overly outgoing personality and carefree attitude.The 68-year-old retired professional wrestler certainly knew how to live his life, and admitted his penchant for consuming alcohol on a daily basis.ADVERTISEMENT LATEST STORIES Winter storm threatens to scramble Thanksgiving travel planscenter_img What he initially thought as a minor issue turned out to be way worse, as his kidneys began to shut down and was on the brink of congestive heart failure, according to The New York Post.“My daughter [Charlotte] told me that the doctor told her to go see me — that I wasn’t going to make it,” Flair shared. “I had no idea it was that bad. Wendy never told me.”As it turned out, Flair’s years of alcohol abuse was the main culprit—a condition he didn’t even know he had.“I didn’t think I was an alcoholic, but obviously I was,” he admitted.Flair also confessed that he had never taken a pain pill in his life, but often relied on booze to ease the pain from his wrestling injuries.ADVERTISEMENT But a after a recent health scare that nearly cost him his life, Flair has changed his tune and has vowed to “never drink again.”WWE: Pro wrestler Ric Flair out of surgery and restingFEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games opening“It scared the sh*t out of me,” the “Nature Boy” recalled his harrowing experience in an interview with People TV.  “I never want to go through this again.”Flair recalled experiencing an upset stomach last month, which prompted his fiancee, Wendy Barlow, to rush him to the hospital. Lacson: SEA Games fund put in foundation like ‘Napoles case’ Hotel says PH coach apologized for ‘kikiam for breakfast’ claim FEU sends UST reeling to fourth straight loss Trump to designate Mexican drug cartels as terrorist groups Don’t miss out on the latest news and information. ‘A complete lie:’ Drilon refutes ‘blabbermouth’ Salo’s claimslast_img read more

Bleak future beckons for England’s weak spinners

first_imgEngland’s humiliating series defeat in India painfully exposed an alarming paucity in the side’s slow bowling options and drove home the fact they will continue to struggle in South Asia until they unearth some world class spinners.Retired off-spinner Graeme Swann had bemoaned England’s indifferent approach towards slow bowling before the five-match series started and his fears were confirmed after the touring side were handed a 4-0 drubbing. (Also read: England need Alastair Cook more as batsman than as captain: Michael Vaughan)The alarm bells would have been ringing when England’s spinners were out-bowled in Bangladesh in October, where the side lost their first ever Test against the hosts in a series regarded by many as an appetiser for the Indian leg of the trip.That 1-1 drawn series did little to prepare England’s batsmen for the main course as India’s spin duo of Ravichandran Ashwin, the world’s top-ranked Test bowler, and Ravindra Jadeja helped themselves to 54 wickets.By comparison, England’s main spinners Adil Rashid and Moeen Ali combined for 33 wickets, and the other four slow bowlers used on the tour – Zafar Ansari, Liam Dawson, Gareth Batty and part-timer Joe Root – only claimed seven more between them.”I think everyone can see we are suited to playing in seaming conditions,” Cook said. “There’s no point hiding behind that fact.”These conditions have tested us to our limits and I really don’t want to be disrespectful to Mo and Adil but they are not as good as Ashwin and Jadeja yet. (Also read: England dressing room a tough place to be in at the moment: Alastair Cook)advertisement”They haven’t quite got the control and consistency, certainly in the first innings when there’s not much happening.”ANDERSON DISAPPOINTSOn their last trip to India in 2012, Swann and his left-arm spin colleague Monty Panesar took more wickets than the hosts’ two leading spinners of Pragyan Ojha and Ashwin and that translated into a 2-1 series victory for England.Cook would have hoped his spinners could turn the screw on India after the touring side made first innings totals of 400 and 477 in Mumbai and Chennai, but England barely threatened with the ball and lost both matches by more than an innings.The captain accepted their current resources were lacking and pleaded for a full-time spin bowling coach for a side who only had former Pakistan off-spinner Saqlain Mushtaq with them as a consultant until the third Test in Mohali.James Anderson, England’s most prolific wicket-taker, had taken 12 wickets in the four Tests in 2012, prompting then India skipper Mahendra Singh Dhoni to dub the seamer as the difference between the sides.However, the injury-hampered 34-year-old went wicketless in Mohali and Mumbai and was a huge letdown for the England attack.The tourists were also let down by some bizarre selection choices during the series.England picked Batty as an extra slow bowler on a Mohali strip known to be one of the country’s least spin-friendly wickets, while the tourists opted for an extra seamer in Mumbai, where Indian spinners bagged 19 out of their 20 wickets.last_img read more

Las Páginas Verdes: Catalyzing Responsible Consumerism in Mexico

first_imgLast week, our New Ventures Mexico team announced the creation of Las Páginas Verdes (“Green Pages”), the country’s first sustainable products and services guide aimed at helping consumers make sustainable decisions about their purchases.Key features will include:A free listing of hundreds of companies that provide sustainable substitutes for common products An online version with search capability Formatted to be as easy to use as the Yellow PagesLas Páginas Verdes is a major milestone in Mexico’s nascent responsible consumer movement. The original concept for this guide arose from a realization by our New Ventures Mexico team that the sustainable enterprise development services we offer could not by themselves bring about the kind of paradigm shift that could mainstream triple-bottom-line business.Las Páginas Verdes was created with the idea that a demand for sustainable products and services existed in Mexico, but that this demand was untapped because of the difficulty for consumers in knowing what sustainable alternatives exist for different products and how to obtain them.The result is a new guide intended to be a user-friendly tool that essentially does the research for the consumer, thereby connecting the kind of sustainable businesses mentored by New Ventures Mexico with the national marketplace. This connection breaks through the bottleneck caused by low consumer awareness and could help drive a new culture of sustainable consumption in Mexico.Mexico City is a good place to start this push for responsible consumerism, where New Ventures expects the guide to reach an estimated 600,000 people within the first year. Subsequent releases will follow in Guadalajara and Monterrey.Of course responsible consumerism is no panacea for the major environmental challenges we face, and should not be sold as a feel-good substitute for effective regulation or conservation efforts. It is just one crucial component of a larger change in the way we think about Earth’s limited resources and the well-being of people who use those resources; whether they are next door or 5,000 miles away.More than anything, Las Páginas Verdes is intended to help catalyze this overdue mentality by giving consumers in Mexico a chance to start choosing a more sustainable lifestyle.last_img read more

A Look Inside Disney’s New Paper Sourcing and Use Policy

first_imgDisney, one of the world’s largest media companies, made a big announcement today that can help the company move in a more sustainable direction when it comes to paper sourcing and use. This is a positive step toward environmental leadership by a company whose name is familiar to people around the globe.According to the policy, Disney will minimize paper consumption in its day-to-day operations and increase the recovery of used paper and packaging for recycling. In terms of paper purchasing, the policy addresses most of the themes covered in WRI’s Sustainable Wood and Paper Procurement Guide. Disney commits to maximize the use of recycled fiber, maximize the use of paper made from wood sourced from sustainably managed forests (as certified by the Forest Stewardship Council or an equivalent forest certification scheme), and maximize the use of paper products processed without chlorine or chlorine compounds. Disney will also eliminate the use of paper made from “unwanted” raw materials including:* illegally-harvested wood;wood from high conservation value areas that are being degraded by poor land use practices;wood harvested in violation of internationally accepted instruments and treaties that protect the rights of indigenous or forest-dependent peoples;wood from areas that have been converted after November 1994 from natural forests to forest plantations or other land uses; andwood from plantations using genetically modified trees.Of course, it will be important for Disney to follow-through on its guidelines and put policies into action to ensure that it follows a sustainable path with its sourcing and use of paper. (Read more about Disney’s new policy on Marc Gunther’s blog).Global Action by a Global BrandThis is a significant announcement, as it comes from one of the largest media conglomerates in the world. Its brands and characters are well known by people of all ages across the globe. Besides the company’s visibility, the policy is ambitious: It applies to the Walt Disney Company and all of its affiliates (e.g. Disney Channels, ESPN, ABC, Hyperion Books, Disney parks and resorts, Disney studios, Disney consumer products, and Disney interactive), and it applies to the paper used in all Disney-branded products (including licensed products), and in day-to-day operations. Because of the potentially large amount and variety of products involved, the policy could have implications for a large number of supply chains and actors throughout the world.Challenges and the Road AheadThe challenges to successfully implement the policy are likewise significant. As a first step, it’s important to understand what the company’s paper usage is, where paper products come from, and what the supply chains providing those products look like. Disney recognizes the challenge and the early implementation phases that are devoted to this.Because wood undergoes a significant transformation to become paper, it’s difficult to trace paper products to the exact forest of origin. But it is possible to track down the products to a level detailed enough to be able to assess risk of sourcing unwanted raw materials. There are standards to help verify the legality and origin of wood and paper products, as well as technologies that can trace, monitor, and compile information about products through the supply chain. Conducting random audits and fiber analyses can also help verify the makeup of raw materials and their origin.Disney is not alone in its forest stewardship policies. Other leading companies, including members of the Forest Legality Alliance and WRI’s Corporate Consultative Group, have put paper purchasing policies in place that take similar approaches. For instance, several other policies recognize forest certification as evidence of responsible forest management and legality of forest products, request additional safeguards (e.g. certification, legality verification) in areas deemed to be of high risk, or prioritize action in areas or products where the company has more control. WRI is currently developing case studies to explore how different companies implement their paper and wood procurement policies.WRI is encouraged by Disney’s step forward. We hope that Disney—as well as other companies—will continue to promote policies that build a demand for paper products sourced from sustainably managed forests.Note: WRI served as an informal advisory to help Disney develop its paper sourcing and use policies. Disney is a member of WRI’s Corporate Consultative Group and the Forest Legality Alliance.last_img read more

Clean Power Plan Can Help States, Economy and Planet

first_imgThis article by WRI Board Member Bill Richardson was originally published by Thomson Reuters Sustainability.As a former U.S. energy secretary, UN ambassador and governor of New Mexico, I’ve watched the debate over the Clean Power Plan with keen interest, and I’m hardly alone. This common-sense rule to cut dangerous air pollution and heat-trapping emissions by power plants in the United States has drawn more than 4 million comments in the last year. Now that it has been officially released, it’s important to understand how CPP can help U.S. states and the national economy, while putting the United States in a leadership position in dealing with the international issue of climate change.First, the plan will make our air safer to breathe by reducing Americans’ exposure to particulate matter and ground-level ozone, benefiting our health and the economy by an estimated $25 billion to $65 billion – far more than the $7 billion to $9 billion cost of compliance, according to the Environmental Protection Agency.Positive Economic ImpactBut this is only the beginning of the new rule’s potential to spur the U.S. economy, which is likely to grow from $17 now to $24 trillion over the next 15 years. The Energy Information Administration projects new rule’s impact on GDP will be one-tenth of a percentage point, and the impact on unemployment will be essentially zero. That’s consistent with the long-term economic impact of previous environmental progress: U.S. GDP grew by 195 percent between 1970 and 2006, even as the Clean Air Act significantly decreased carbon monoxide, nitrogen dioxide and sulfur dioxide pollution.Our economy thrives when we tackle pollution, and that’s what the Clean Power Plan can do, avoiding up to 6,600 premature deaths, as many as 150,000 asthma attacks in children and up to 490,000 missed days of work or school, totaling $93 billion in benefits to public health and our climate.What will the new rule mean for individual states and their economic success? As a former governor, I know citizens want a clean environment, but not at the expense of a vibrant economy. The latest research shows we can have both, if we’re willing to invest in innovative technology, including technology that fosters renewable energy including solar and wind power.The good news is that raising the percentage of renewable energy is something many states are already doing, to their own benefit. Some states already are aiming to reap annual electricity savings of 2 percent of sales or more. Factor in the rapidly falling prices of renewable energy technologies and the significant potential for future growth in this sector, and the economic opportunity for states is clear. The new rule’s targets encourage this sensible move toward lower-carbon energy. It offers states ample flexibility to design approaches that work best for them, letting them provide the most cost-effective, reliable electricity supply to their consumers. In fact, in the final rule, EPA has combined additional flexibility on compliance dates with incentives on renewables and energy efficiency, which will likely lead to more robust implementation across the country.More than Dollars and SenseThe Clean Power Plan addresses more than dollars and sense. On a global level, it sets out a practical framework that will enable the United States to reach its short- and medium-term goals to reduce emissions that contribute to a changing climate, and to take its place in the forefront of nations working on an international pact to tackle this issue.By addressing the single-largest source of U.S. greenhouse gas emissions, this plan is one of the most important near-term tools the country can use to help reach its goal of reducing emissions 26-28 percent below 2005 levels by 2025. The incentives for early action by the states will help ensure that the 2025 target is met. The plan also demonstrates to the world that the United States will lead global efforts to address climate change and stands poised to meet or exceed its short and mid-term climate change goals.As droughts, heat waves, floods and other extreme climate events strike parts of the United States; the reality of climate change’s impact is evident. Because this is a global problem, it requires action from all countries. Those with the highest greenhouse gas emissions, including the United States, need to take the lead. By starting to act to curb our emissions at home, we can spur the global action we need.The U.S. power sector has started to “decarbonize” by cutting its carbon emissions, and the Clean Power Plan can accelerate the trends toward clean energy investment and energy efficiency that already exists across the country. But the United States isn’t the only nation committed to these essential changes.China, the world’s top emitter of greenhouse gases, is also the Number 1 investor in renewable energy. To support its goal of having its emissions peak by around 2030, China has committed to increase the share of non-fossil fuels in its energy mix by about 20 percent over the next 15 years. In India, Prime Minister Narendra Modi’s new government aims to install 100 gigawatts of solar generating capacity by 2022, more than eight times the current U.S. capacity. Brazil, another fast-growing economy, is taking important steps to avoid deforestation and increase its share of renewable to 20 percent by 2030. Building on these heartening developments, and with U.S. leadership, there’s great potential for a global climate agreement in Paris this December.last_img read more

Proficiency in Math and Science Critical – Minister Paulwell

first_imgMinister of Science, Technology, Energy and Mining, Hon. Phillip Paulwell, says Government has identified the critical need to build proficiency in science and mathematics to transform the economy and create a more sustainable future. “Jamaica’s future lies in developing a technology savvy, knowledge-based economy, where our people have the skills to compete with others anywhere in the world and the creativity to innovate new products and processes,” he stated. “Countries that invest in their students mastering science and mathematics are the internationally competitive economies of the world today (such as) Japan, the United States of America, Germany, South Korea, Brazil, China, and India,” Minister Paulwell added. He was delivering the keynote address at the official opening of the 5th Annual Mathematics and Science Competition and Exhibition on Wednesday, March 13, held on the grounds of Cornwall College in Montego Bay, St. James. The Minister informed students that workers with a strong background in science and mathematics are going to be needed for the industries that will come on stream in the next five to 10 years. Among the skilled personnel needed are computer technicians, application developers and other Information and Communications Technology (ICT) entrepreneurs and experts, both for the business process outsourcing centres, as well as for the proposed logistics hub. “We need earth scientists, geologists, cartographers, marine biologists and many more to help Jamaica pursue its oil and gas exploration. We also need engineers, machinists, technicians and many more to build and maintain the solar and wind equipment for the renewable energy sector,” Mr. Paulwell said. Pointing to the economic potential of the red mud industry, Minister Paulwell told the students that the country could earn far more foreign exchange if production of the minerals could be done in Jamaica. “We can have Jamaicans build and run this industry completely, but only if we get more of our students leaving university with degrees in biology, chemistry, physics, geology, math and so on,” he pointed out. “You are the ones who I am counting on to become the statisticians, the chemists, the machinists, the analysts, the lab technicians, the engineers and the researchers for this evolving industry,” he told the students. Minister Paulwell congratulated the more than 500 students from western Jamaica, who are taking part in the mathematics and science competition, and expressed the hope that the contest, which gets bigger and better each year, will become a national event. By Glenis Rose, JIS Reporterlast_img read more

CONGRATULATIONS TO CASTING DIRECTOR STEVEN MANN – Respect The Sole A New

first_imgREAD MORE Facebook Advertisement Login/Register With: Advertisement LEAVE A REPLY Cancel replyLog in to leave a comment Sneakers and Hip-Hop have been hand-in-hand for more than 30 years. In 1986 Run-D.M.C. screamed “My Adidas” so loud that the German apparel brand responded with a check. That relationship has evolved to JAY-Z, 50 Cent, and Kanye West signing off on shoe lines, and some equally great Rap lines by Ice Cube, KRS-One, Ghostface Killah, and many others endorsing their sneakers of choice.One piece of footwear that’s been timeless throughout the lifetime of Hip-Hop is the straightforward high-top sneaker. Starting with the pioneering Converse Chuck Taylor All-Star, this type of shoe is celebrated for its durability, fit, and literal canvas for artists. Like records, aerosol paint, or rhyming words, they also have long beckoned the custom touch. TRPL is a company that has seamlessly blended the culture of Hip-Hop music with sneakers, by way of their custom hi-top kicks (and matching boxes). “Respect the sole” is not only the company’s tagline, it appears to be a deeper philosophy.Business partners Steven Mann (a Casting Director and former Hip-Hop journalist) and Danny Shaw launched TRPL. The company also boasts Grammy Award-winning MC/producer Vin Rock of Naughty By Nature as its Product Ambassador. Advertisement Twitterlast_img read more

UN independent expert voices concerns over the practice of targeted killings

Philip Alston, the UN Special Rapporteur on extrajudicial executions, said in a new report that legal justifications for targeted killings were often based on “excessively broad circumstances” and there was a lack of essential accountability mechanisms to ensure that they were legal.“In terms of the first problem, there are indeed circumstances in which targeted killings may be legal,” Mr. Alston noted. “They are permitted in armed conflict situations when used against combatants or fighters, or civilians who directly engage in combat-like activities.“But they are increasingly being used far from any battle zone. The United States, in particular, has put forward a novel theory that there is a ‘law of 9/11’ that enables it to legally use force in the territory of other States as part of its inherent right to self-defence on the basis that it is in an armed conflict with al-Qaida, the Taliban and ‘associated forces’, although the latter group is fluid and undefined.“This expansive and open-ended interpretation of the right to self-defence goes a long way towards destroying the prohibition on the use of armed force contained in the UN Charter. If invoked by other States, in pursuit of those they deem to be terrorists and to have attacked them, it would cause chaos,” Mr. Alston writes in his report to the UN Human Rights Council.He emphasized that he did not question the seriousness of the challenges posed by terrorism, saying he wholeheartedly condemned actions of al-Qaida and other groups that killed innocent civilians, as well as those that increased the danger of attacks on civilians by hiding in their midst.“But the fact that such enemies do not play by the rules does not mean that a government can cast those rules aside or unilaterally re-interpret them. The credibility of any government’s claim that it is fighting to uphold the rule of law depends on its willingness to disclose how it interprets and applies the law – and the actions it takes when the law is broken,” according to Mr. Alston.On accountability, Mr. Alston observed that international law requires that States using targeted killings demonstrate that they are complying with the various rules governing their use in situations of armed conflict.“The clearest challenge to this principle today comes from the programme operated by the United States’ Central Intelligence Agency (CIA) in which targeted killings are carried out from unmanned aerial vehicles or drones. It is clear that many hundreds of people have been killed as a result, and that this number includes some innocent civilians,” Mr. Alston said.“Because this programme remains shrouded in official secrecy, the international community does not know when and where the CIA is authorized to kill, the criteria for individuals who may be killed, how it ensures killings are legal, and what follow-up there is when civilians are illegally killed.“In a situation in which there is no disclosure of who has been killed, for what reason, and whether innocent civilians have died, the legal principle of international accountability is, by definition, comprehensively violated,” Mr. Alston said.He contrasted the lack of accountability during targeted killings to the established practice in the United States Department of Defense, where controversial military decisions can be reviewed.“While it is by no means perfect, the United States military has a relatively public accountability process, as demonstrated earlier this week by its report on the incident in Uruzgan, Afghanistan, in which at least 23 civilians were killed based on erroneous intelligence from surveillance drone operators,” Mr. Alston said.“Intelligence agencies, which by definition are determined to remain unaccountable except to their own paymasters, have no place in running programmes that kill people in other countries,” Mr. Alston added.The Special Rapporteur reports to the Human Rights Council, which is based in Geneva, and serves in an independent and unpaid capacity. 2 June 2010A United Nations independent human rights expert today sounded the alarm about the practice of targeted killings, saying it had a tenuous legal basis and could undermine the rules that aim to prevent extrajudicial executions and guarantee people the right to life. read more

WatchLooming carbon tax leaving businesses very freaked out amid confusion lack of

OTTAWA — Canada’s small business operators say they are not ready for the carbon tax to kick in next week — particularly since the federal government has still not told them how they will be compensated for the cost.The federal carbon pricing backstop kicks in April 1 in the four provinces that didn’t have their own carbon pricing system — Saskatchewan, Manitoba, Ontario and New Brunswick. Nunavut and Yukon, both of which asked to use the federal system, will start on July 1.More than half a million businesses will be affected.Ottawa has promised to return all the funds collected in rebates to individuals, businesses, local governments and other organizations. The rebates for individuals are already flowing as tax returns get filed, but the promised program to help small and medium businesses hasn’t been finalized. Carbon-tax backstop leaves small businesses at pointy end of pricing-adjustment stick: CFIB Canada imports more emissions than exports, so why are we the ones paying carbon taxes? Doug Ford says the Liberals’ carbon tax will plunge Canada into recession “These are rebates of some nature yet to be determined,” said Dan Kelly, president of the Canadian Federation of Independent Business.Kelly also said “small firms are still very freaked out” by the coming carbon price, with a lot of unanswered questions about how it will work, who might get an exemption and what documents will be required to prove payment or exemptions. Operators are also wondering who is required to register with the Canada Revenue Agency to collect or apply the charge, and for whom registration is optional.“There is a dearth of information out there about how this is going to work,” he said. “There’s a whole bunch of technical questions and we’ve gone to the feds with these questions and they’ve come up short in terms of answers. Yet we’re a week away from the tax being in place.”The CFIB wants an assurance that businesses won’t be hit with big fines if they make a mistake in the early days of the program.The tax is being applied starting at $20 per tonne of greenhouse gas emissions produced, rising to $50 by 2022. It applies to 21 different input fuels and combustible materials used to produce energy, including gasoline, diesel, aviation fuel, tires and asphalt shingles. The expectation is that at $20 a tonne, a tank of gas will cost about $2 more, and a monthly natural gas heating bill will go up $8.The tax will generally be applied early in the supply chain by a fuel distributor, and ultimately built into the price paid by the end user. It will be harder to gauge the impact on prices of consumer goods that will cost more to produce or transport as businesses pay the tax on their energy inputs.Kelly said businesses expect to shoulder the weight of about 50 per cent of the burden of the carbon price, but are only getting seven per cent of the rebates — an imbalance he called “grossly inadequate.”The assumption that businesses will be able to just increase prices to offset their costs is wrong, he added, noting that a majority of CFIB members say in order to remain competitive, they won’t be able to pass along the burden to consumers.Ottawa is giving individuals cash rebates averaging between $248 and $598 per household, depending on sources and energy use.For businesses without big emissions, however, the rebates will be made to offset investments businesses make to cut their energy use or switch to greener sources.An estimated $155 million is to be made available in 2019-20 for businesses, and $1.5 billion over the next five years.Environment Minister Catherine McKenna has said the final details of the business rebates were still being worked out. Last week’s federal budget made mention of legislation to allow the funds to be transferred, but offered no specifics.A spokesman for the Canada Revenue Agency, which is administering the carbon price, said in a statement the agency is aware registering for the new fuel charge may cause some concern for many businesses. However, he said the CRA began informing the affected sectors last fall through a series of “fuel charge webinars” as well as in direct meetings with different industries.There are also documents available online to help and CRA staff can answer questions through any regional office, he said.Conservative environment critic Ed Fast said small businesses are “going to suffer the most” from the carbon price and are getting the least help.The Conservatives have promised to do away with the carbon price if they win the next federal election, scheduled for October. read more

Most actively traded companies on the TSX TSX Venture Exchange markets

TORONTO – Some of the most active companies traded Wednesday on the Toronto Stock Exchange and the TSX Venture Exchange:Toronto Stock Exchange (13,304.92 down 14.95 points):CGI Group Inc. (TSX:GIB.A). Information technology. Down $1.49, or 3.87 per cent, at $37.03 on 6.38 million shares.Sirocco Mining Inc. (TSX:SIM). Up 35 cents, 9.21 per cent, at 41.5 cents on 6.40 millin shares. Toronto-based Canada Lithium, which has an advanced lithium project in Quebec, is offering shares worth about $120 million based on recent market prices to acquire iodine producer Sirocco. Assuming the deal closes, shareholders of Vancouver-based Sirocco would own 42 per cent of the combined company.Delphi Energy Corp. (TSX:DEE). Oil and gas. Up eight cents, or 5.13 per cent, at $1.64 on 5.62 million shares.Surge Energy Inc. (TSX:SGY). Oil and gas. Down 14 cents, or 2.07 per cent, at $6.62 on 4.68 million shares.Petrominerales Ltd. (TSX:PMG). Oil and gas. Up a penny, or 0.08 per cent, at $12.26 on 4.67 million shares.Toronto Venture Exchange (919.52 up 4.23 points):Midlands Minerals Corp. (TSXV:MEX). Miner. Up half a cent, or 100 per cent, at a penny on 14.70 million shares.Corsa Coal Corp. (TSXV:CSO). Miner. Up a penny, or 7.14 per cent, at 15 cents on 10.98 million shares.Companies reporting major news:Barrick Gold (TSX:ABX). Miner. Up 21 cents, or 1.27 per cent, at $16.72 on 4.64 million shares. Founder Peter Munk will retire from the board of Barrick Gold Corp., as part of broad changes at the world’s largest gold producer. Former Goldman Sachs executive John Thornton will be named chairman while two long-time directors will not stand for re-election. Barrick has faced difficult times this year as it has taken billions in writedowns, suspended work at its massive Pascua-Lama project in South America and slashed its dividend.National Bank (TSX:NA). Bank. Down $1.37, or 1.51 per cent, at $89.53 on 1.52 million shares. Fourth-quarter revenue and net income at Canada’s sixth-largest bank were down from a year earlier amid more difficult conditions in the financial services sector. The bank also announced the banking sector’s first stock split in more than seven years. National, which is optimistic about the economy, is boosting its quarterly cash dividend by six per cent to 92 cents per share, starting Feb. 1 Most actively traded companies on the TSX, TSX Venture Exchange markets AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email by The Canadian Press Posted Dec 4, 2013 3:32 pm MDT read more

South Sudan civilians fleeing violence nears 2 million with no likelihood of

Referring to the damaging impact of the conflict on human rights across the country, including gross violations committed by all parties to the conflict, such as extra-judicial killings, enforced disappearances, rape, other forms of sexual violence, and attacks on hospitals and UN facilities, Flavia Pansieri noted that the scale and severity of reported violations had declined compared to the first months of the conflict.“However, civilians have continued to bear the brunt of the ongoing armed conflict and of their leaders’ failure to stop the fighting,” she said in her remarks to a panel discussion on South Sudan held by the UN Human Rights Council in Geneva. Both the South Sudan Government and the Sudan People’s Liberation Movement/Army in Opposition have continued to mobilize forces and amass weapons in an effort to consolidate their respective power bases, she said.“The numbers of civilians displaced across and from South Sudan has continued to rise, with no likelihood that people will return to their homes soon,” she said. “Since the conflict began in December 2013, some 1.5 million people have been internally displaced inside the country and a reported 400,000 people have sought refuge in neighbouring Kenya, Uganda, Ethiopia and the Sudan.”Ms. Pansieri also reported the country is experiencing extreme food insecurity and facing a possible famine.Yesterday, the UN Food and Agriculture Organization (FAO) said the combined efforts of the agency, the World Food Programme (WFP) and Mercy Corps have helped to pull 2 million people back from the brink of famine and severe food insecurity in South Sudan.“This progress, however, is fragile, partial, temporary and expensive. Despite current short-term improvements, 1.5 million people are projected to remain severely food insecure until the end of 2014, which is a 50 per cent increase from December 2013,” FAO said in a news release.Last month, the UN declared that the South Sudan aid operation is the biggest of any single country, “but that it still falls far short in the face of overwhelming needs,” Ms. Pansieri said.And the reports of killings and wounding of civilians by all parties to the armed conflict and other armed groups have continued unabated, she said.The UN Mission in South Sudan (UNMISS) has opened its gates to civilians who fled the violence. Around 100,000 internally displaced persons are now seeking shelter in Protection of Civilians sites within UNMISS compounds – an entirely unprecedented influx in the history of the UN, which presents the Mission with unique challenges.The Deputy High Commissioner recommended that more needs to be done to protect civilians and to ensure accountability for crimes and human rights violations.“Up to now, neither the Government nor the [opposition] SPLM/A-IO has demonstrated any real interest in ensuring accountability for widespread violations and abuses committed in the course of the conflict,” she said.She urged the international community to put pressure on the country’s leaders to prevent further violations by forces under their command and to make it clear that anyone committing crimes and human rights violations will be arrested and prosecuted. read more

Global spotlight on world drug problem is personal for many families says

Drug addiction is “more than just a policy issue. It is personal.”  Mr. Guterres said at the event, noting that “the reality is that drugs and addiction are not abstract issues.”“All of us have stories” and “it is our duty to act – and act now,” underscored the UN chief.He highlighted that he had lost a friend to drugs “at an unbearably young age, and also described how his sister had spent many years working as a psychiatrist at a drug treatment centre in the Portuguese capital, Lisbon.“I saw the heavy toll it took on her day after day as she treated those suffering so badly,” he said, adding that he had “enormous admiration” for her. “I think I have done several tough jobs in my life. Nothing compares with what I have seen her do.”Calling the situation “alarming,” Mr. Guterres pointed out that the global production of opium and manufacture of cocaine “has never been higher.”“Some 450,000 people die every year from overdoses or drug-related health issues,” he underscored, adding that in recent years, “some 31 million people around the world” required drug-addiction treatment.Non-medical use of tramadol in parts of Africa and the Middle East is threatening communities that are already fragile. And the United States is in an “utterly heart-breaking” opioid crisis, according to the UN chief.He voiced concern that only one-in-six people who need drug-addiction treatment receives it, and for women, the figure is even higher.National priorities may differ, but the global community shares a common goal: to protect people’s security, health and wellbeing – UN Secretary-GeneralMr. Guterres urged “strong action in two areas” to tackle this issue.Firstly, he underscored the urgency to “crack down on drug trafficking and those who profit from human misery,” specifically by denying them safe havens and better cross-border cooperation; improving intelligence-sharing and analysis across drug supply chains; and targeting the links between drugs, corruption, arms, human trafficking and terrorist networks. Secondly, he called for the need for drug-addiction treatment, with consumers being “first and foremost, patients and victims.” The Secretary-General explained that this was the policy he employed as Portugal’s Prime Minister two decades ago, when the country had some of Europe’s highest drug abuse death rates and the highest rate of HIV amongst injecting drug users.”And the policy worked,” he stated. “There was an increase in the quantity of drugs seized and in the efficiency of police and customs operations.”Moreover, he said that drug consumption dropped “significantly, particularly among youth,” drug users declined by 50 per cent, and drug-related infectious diseases and the number of people overdosing also plunged.“National priorities may differ, but the global community shares a common goal: to protect people’s security, health and wellbeing,” he emphasized.Mr. Guterres assured that the UN stands behind the UN Drug Control Conventions and the 2016 UN General Assembly Special Session outcome document.”The United Nations system – and I personally – stand ready to support governments in meeting the challenge of the world drug problem,” he asserted.“Failure is, indeed, not an option.  Together we will succeed. We will never give up,” concluded the Secretary-General. UN Photo/Mark GartenUS President Donald Tump presents his Global Call to Action on the World Drug Problem during the high-level event on countering narcotics at UN Headquarters.“Deliver a drug-free future”US President Donald Trump, hosting the event, called Mr. Guterres a “great friend,” noting that he was doing a “wonderful job” in a “very complex” situation, adding that the UN’s “tremendous potential” was “slowly but surely” being met.The US President stressed the need to combat drug addiction and stop all forms of trafficking and smuggling.”The scourge of drug addiction continues to claim too many lives in the US and the nations around the world,” said Mr. Trump. “Today we commit to fighting the drug epidemic together.”Citing the 2018 World Drug Report, he pointed out that cocaine and opium production have hit record highs, noting that global drug-related deaths have gone up 60 per cent in 15 years.Flagging the link between illicit drugs and organized crime, illegal financial flows, corruption and terrorism, he stressed: “It is vital for public health and national security that we fight drug addiction and stop all forms of trafficking and smuggling that provide the financial lifeblood for vicious trans-national cartels.”“All of us must work together to dismantle drug production and defeat drug addiction,” he underscored, recalling the US’ call-to-action last month on the world drug problem: “Reduce drug demand, cut off the supply of illicit drugs, expand treatment and strengthen international cooperation.”“If we take these steps together, we can save the lives of countless people in all corners of the world,” said Mr. Trump. “The United States looks forward to working with you to strengthening our communities, protect our families and deliver a drug-free future for all of our children. read more

Ohio State mens hockey falls in Big Ten Tournament ending its season

Sophomore forward Nick Schilkey (37) controls the puck during a game against Minnesota on March 6 at the Schottenstein Center. OSU lost, 4-2.Credit: Kaley Rentz / Lantern reporterThe Ohio State men’s hockey team arrived at the Big Ten Tournament confident and motivated.The Buckeyes (14-19-3, 8-11-1) turned that into a 3-1 win against Penn State in the Big Ten quarterfinals, but couldn’t make it pass the semis. OSU’s confidence and motivation wasn’t quite enough, as the Buckeyes lost to No. 13 Minnesota, 3-0, to end their season Friday evening.Even though the Buckeyes didn’t make the championship game, coach Steve Rohlik had a positive outlook on the losing season. While he said he was proud of the team as a whole, Rohlik stressed the importance of the Buckeyes’ upperclassmen.“I’m even prouder of our eight seniors,” he said. “What they’ve done for our program, they’ve sent this program in the right direction. So, obviously I thank them.”Senior assistant captain forward Matt Johnson said even though the end result was disappointing, he was proud of his teammates’ desire to end the season confident and unified.“We really found our identity and started to roll with it,” Johnson said. “Going off of last year, we were very confident, just like this year, we beat every team in the conference. There was nobody we didn’t think we could beat.”Moving forward, the Buckeyes will be without eight seniors, who have seen the program transition from the hiring of a new head coach and a change of conference to the Big Ten from the Central Collegiate Hockey Association.“It’s really an incredible group,” Rohlik said. “They’re the ones that have been a big part of where this culture is and where it’s going. Their leadership pulled us along over the last couple months. They’re a big part of why we had a chance.”For Johnson and senior captain forward Tanner Fritz, the final game was emotional, but the two said they are excited for the program’s future.“​I see the program going, obviously, in the right direction,” Johnson said. “We do everything right here. We do it the right way. We have the great staff. To me, you just can’t get a better program.”“We’re always pushing to get better, and I know they’re going to do that in the following years,” Fritz added. “The only way to go is up from here.”Next year, the Buckeyes will look toward a new group of upperclassmen to lead them in the right direction.OSU has three key players returning in captain Sam Jardine, leading goalscorer Anthony Greco and 6-foot-5-inch defenseman Craig Dalrymple.   Beyond that trio, forward Nick Schilkey, defenseman Josh Healey and goaltenders Christian Frey and Matt Tomkins are all set to be back for another season as well.But regardless of the players, Rohlik said the team’s progression starts with the coach.“I mean, first and foremost, I’m going to have to take some time to reflect on myself because it starts with me,” Rohlik said. “I’ve got to be better.”With the return of a solid foundation, Rohlik said he is eager for the Buckeyes to come out with swagger, determination and success in the Big Ten next year.“The one thing that I want is to let people know we’re going to show up every night,” Rohlik said. “We’re going to come at you and play hard and our guys are going to leave it on the line. That’s our identity and that’s what we try to leave here today.” read more

Builder who passed off wifes murder as suicide jailed after pub confession

Victoria Bull, one of Mrs Potter’s two children from her first marriage, said the day of her mother’s death was one of the hardest of her life as she had to tell her children their grandmother had killed herself.But weeks later, she had to tell them that in fact, she had been killed by the man they regarded as their grandfather.”As a parent, you do everything you can to protect your children – but I could not protect them from this,” she said.The Potters’ daughter Nicole Njegovan, said:  “I was four months’ pregnant at the time and I at first I was very sad and angry at my mum thinking that she had left me.”She said she found it very hard to come to terms with her father murdering her mother, adding: “I will forever grieve for her.”Paul Hobson, prosecuting, told Mr Justice Soole: “It is plain, on the day of Lesley Potter’s death the police response was not as it should have been and mistakes were made, either of common sense or procedure or of both.”We know scenes of crimes (officers) attended and took photographs but there was no wider inquiry than that. There was no action by CID and the force medical examiner. Miss Mikhailoea-Kisselevskaia tipped off the police and a “full investigation” was launched, with Mrs Potter’s body taken from the chapel of rest for a post mortem.The court heard that she had several internal injuries, 30 rib fractures and more than 30 bruises over her neck, face, arms, back, legs and feet.Elwen Evans QC, prosecuting, said: “Mr Potter killed his wife by strangling her, using his hands.”He then tried to cover up what he had done by pretending she had suspended herself with a ligature. He almost got away with that pretence.”Potter denied murder and claimed his wife killed herself or could have died while choking herself for sexual pleasure.He claimed Miss Mikhailoea-Kisselevskaia had misunderstood what he told her.But a jury took just one hour and 11 minutes to find him guilty of murder.Jailing Potter for a minimum of 17 years, Mr Justice Michael Soole branded his staged hanging a “shameful and despicable charade” which exposed his wife’s body to “terrible indignity and dishonour”.He added: “It was a ferocious attack. I’m sure than in the moment he strangled your wife that you intended to kill her. You knew what you were doing.” “What happened in this case is something (the police) have been looking at very seriously with a view to making improvements in regard to sudden deaths.”Lesley Potter’s family were told one thing, then another thing some time later. No family should have to deal with that.”South Wales Police said in a statement: “Now that the criminal proceedings are concluded we will consider the comments made and review the initial police response to this tragic death.” Police errors almost allowed a husband to get away with murdering his wife and staging a suicide until he admitted his crime to a woman in a pub.Derek Potter, 64, throttled his wife of 26 years before setting up their bedroom to make it look as though she had killed herself, Swansea Crown Court heard.Officers from South Wales Police failed to spot anything suspicious, treating the mother-of-three’s death, on April 7, as suicide.They accepted Potter’s claims that he had popped out for 15 minutes and returned to their home in Swansea to find his 66-year-old wife dead.Mrs Potter’s body was released for a funeral service with a cremation organised for May 8.But on April 25, Potter went for a drink with fellow builder Natalia Mikhailoea-Kisselevskaia, 32, at his local pub, The George, and told her what he had done.”We were still on our first pints when he said: ‘I have got to tell you something,’” she told the jury.”He said: ‘I love my wife very much but she was doing my head in so I strangled her’.”She added: “He was saying it with a straight face – no tears in his eyes, no laughter. I thought: ‘Oh my God, he’s done it’.” Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily  Front Page newsletter and new  audio briefings. read more

WWE Network advertising Greatest Royal Rumble Watch WWE Fastlane with NextVR app

first_img WhatsApp House panel demands tech company emails Former Google Engineer Fears Robots Can Cause Accidental Mass Killings Now Playing Up Next Facebook WWE NXT Results – 9/11/19 (Last episode before the USA Network move, Ripley vs. Baszler) Now Playing Up Next Now Playing Up Next Adam Martin RELATED ARTICLESMORE FROM AUTHOR Miz and Mrs. Season One coming to the WWE Network Friday, September 20 Recommended videosPowered by AnyClipGoogle zahlt fast eine Milliarde Euro an FrankreichVideo Player is loading.Play VideoPauseUnmuteDuration 0:48/Current Time 0:04Loaded: 100.00%0:04Remaining Time -0:44 FullscreenUp NextThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Replay the list Google Boosting Original Reporting With Algorithm Change Pinterest WWE Network advertising Greatest Royal RumbleAccording to a report by PWInsider.com, the Greatest Royal Rumble event on April 27 is being advertised as airing on the WWE Network.A reader noted that when they attempted to cancel a subscription to the WWE Network, a screen advertising future live programming was shown including the Greatest Royal Rumble event that will take place from Jeddah, Saudi Arabia.WWE star Roman Reigns noted on the “Jim and Sam Show” on SiriusXM last Friday that the event would be broadcasting on the network, although WWE has yet to officially announce it. Seven championship matches were also announced for the show this week.Tickets for the show officially go on sale beginning March 31.Watch WWE Fastlane with NextVR appWWE has posted a video noting that the Fastlane PPV is now available for viewing as part of the NextVR app. The app is compatible with Gear VR, Google Daydream, Windows Mixed Reality or Playstation VR and is available for a free download.For more information you can visit nextvr.com/wwe. Now Playing Up Next Now Playing Up Next Google va verser un milliard d’euros à la France Google zahlt fast eine Milliarde Euro an Frankreich Google+ Twitter SPOILERS: 9/1 NXT UK TakeOver Cardiff Fallout TV Tapings to air on WWE Networklast_img read more

Elim without potable water boil notice issued

first_imgOne local teacher confirms the Elim Aniguiin school has had early dismissals the past three days, due to a lack of water for students. According to a statement from school staff, the building does not have flushing toilets or water for students to wash their hands. They estimate that they have “just enough to give about a measuring cup of water with each meal.”Laura Achee, a spokesperson for the Alaska Department of Environmental Conservation (ADEC), says the power outage caused the community’s water issues.“Our understanding of the situation in Elim is that there was a power outage that lasted about a day and a half,” Achee said. “Without water pressure in the system, that allowed the tanks to drain, and so it’s our understanding that there is no water left in the system. They are apparently having trouble getting the pumps restarted.”Staff from ADEC’s drinking water program helped inform Achee of the situation, but she says at this time they don’t have any additional information about the amount of water or the source of water Elim has access to. Nor does ADEC know what is preventing the water pumps from coming back online.“We’ve heard that there are folks from AVEC (Alaska Village Electric Cooperative)in the community on a different issue that are assisting in helping get the pumps restarted, but at this time, we have not heard that they have restarted (them),” Achee said.The Elim school expects to be on an early dismissal schedule again today unless the water pressure system comes back on. Elim’s city office could not be reached for comment before the airing of this story.Achee says the boil-water notice will remain in place until the community’s water system has a pressure of 20 PSI and water samples are determined to be clean. Elim in winter. (KNOM file photo)The community of Elim is going into its fourth day without running water, following more than a day without power over the weekend. And as of Tuesday, the state issued a boil-water notice for the Norton Sound coastal community.last_img read more

Full Show Methodists React To LGBTQ Vote And Houstons Extreme 911 Saves

first_img To embed this piece of audio in your site, please use this code: Listen 00:00 /50:25center_img X On Friday’s Houston Matters: Methodist churches across Houston will hold services this weekend just days after leaders of the denomination upheld a policy banning same-sex marriage and LGBTQ clergy. Local Methodist leaders share how they’ll navigate services this weekend in the wake of the divisive decision.Last month, a recluse living in Scotland had a health emergency and sent a distress signal from a satellite tracking device. His call for help was picked up a few thousand miles away near Houston by the GEOS International Emergency Response Coordination Center (IERCC) in Montgomery. We learn how the service works and how it was able to help the man.Also this hour: We break down The Good, The Bad, and The Ugly of the week’s news. And, as we prepare to celebrate another Texas Independence Day, we revisit the story of the original Texans who fought for independence from Mexico.We offer a daily podcast here, on iTunes, Stitcher and other podcasting apps This article is part of the Houston Matters podcast Sharelast_img read more

Microsoft Azure Mastery Bundle Is Being Offered To Users For A 92

first_imgCloud technology is becoming increasingly popular in today’s world. Our reliance on technology has ensured the careers of so many people. A career in cloud technology is definitely something you should look into and if you are already trying to pursue it then you already know about Microsoft Azure. Wccftech is giving users an amazing opportunity and offering an amazing deal on the Microsoft Azure Mastery Bundle. This bundle includes 3 very comprehensive courses that will allow you to prepare for one of the most important certifications of cloud technology.Microsoft Azure Mastery Bundle featuresEvery course in the Microsoft Azure Mastery Bundle has something unique to offer. Read on to find out more about each course.70-532 Developing Microsoft Azure Solutions Certification Access 143 lectures and 8 hours of content 24/7 Master the main concepts of Azure, beyond the ones you normally use Prepare to pass the Microsoft 70-532 Developing Microsoft Azure Solutions examStudy to become Microsoft Specialist: Developing Azure Solutions certified70-533 Implementing Microsoft Azure Access 125 lectures and 8.5 hours of content 24/7Learn how to implement solutions for the Microsoft Azure platform Study to become Microsoft MCP Certified Work towards passing the Microsoft 70-533 Implement Microsoft Azure Solutions exam Stay up-to-date on the latest updates to this ever-changing platform Understand that main concepts of Azure, beyond the ones you normally use70-534 Architecting Microsoft Azure Solutions Access 181 lectures and 10.5 hours of content 24/7 Learn how to save companies millions by implementing Azure cloud technology Work towards passing the Microsoft 70-534 Architecting Microsoft Azure Solutions examGetting Azure on your resume will put you ahead of the ground and you will be able to land more jobs than your peers. Getting a 92% discount on a bundle like this is a great opportunity. So take advantage of it before it is too late.Original Microsoft Azure Mastery Bundle Price: $450 Wccftech Microsoft Azure Mastery Bundle Discount Price: $34 Share Tweet Submitlast_img read more